Recombinant Human FAST kinase domain-containing protein 2 (FASTKD2)

Uniprot Id

Q9NYY8

Target Species

Human

Target Name

FASTKD2

Target Full Name

FAST kinase domain-containing protein 2, mitochondrial

Target Function

Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis.

Target Subcellular Location

Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion matrix.

Target Protein Families

FAST kinase family

Target Tissue Specificity

Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid.

Target Synonyms

FAKD2_HUMAN; FAST kinase domain containing protein 2; FAST kinase domain-containing protein 2; FAST kinase domains 2; Fastkd2; KIAA0971

Target Background

This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency.