Recombinant Human Sorting nexin-15 (SNX15)

Uniprot Id

Q9NRS6

Target Species

Human

Target Name

SNX15

Target Full Name

Sorting nexin-15

Target Function

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.

Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Sorting nexin family

Target Tissue Specificity

Widely expressed.

Target Synonyms

Clone iota unknown protein; HSAF001435; SNX 15; SNX15; SNX15_HUMAN; Sorting nexin 15; Sorting nexin-15

Target Background

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.