Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP11223 | Target Name | UBN1 |
|---|---|---|---|
| Target Synonyms | UBN1; Ubinuclein-1; HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NPG3 |
|---|
Uniprot Id
Q9NPG3
Target Species
Human
Target Name
UBN1
Target Full Name
Ubinuclein-1
Target Function
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Target Subcellular Location
Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Target Protein Families
Ubinuclein family
Target Tissue Specificity
Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
Target Synonyms
UBN1; Ubinuclein-1; HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
