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Recombinant Human Intersectin-2 (ITSN2), Truncated

ACP11400

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Specifications

Cat.No	ACP11400	Target Name	ITSN2
Target Synonyms	ITSN2; KIAA1256; SH3D1B; SWAP; Intersectin-2; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NZM3

Background Information

Uniprot Id

Q9NZM3
Target Species

Human
Target Name

ITSN2
Target Full Name

Intersectin-2
Target Function

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
Target Subcellular Location

Cytoplasm.
Target Tissue Specificity

Expressed in melanocytes. Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.
Target Synonyms

ITSN2; KIAA1256; SH3D1B; SWAP; Intersectin-2; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein
Target Background

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis.

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Recombinant Human Intersectin-2 (ITSN2), Truncated

Specifications

Immunogen Information

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