Recombinant Human Platelet glycoprotein VI (GP6), Truncated

Uniprot Id

Q9HCN6

Target Species

Human

Target Name

GP6

Target Full Name

Platelet glycoprotein VI

Target Function

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

Target Involvement

Bleeding disorder, platelet-type 11 (BDPLT11)

Target Subcellular Location

[Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Cell membrane; Single-pass membrane protein.

Target Tissue Specificity

Megakaryocytes and platelets.

Target Synonyms

Glycoprotein 6; Glycoprotein VI; GP6; GPIV; GPVI; GPVI_HUMAN; MGC138168; Platelet collagen receptor; Platelet glycoprotein VI; Platelet glycoprotein VI precursor

Target Background

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.