Recombinant Human Dual specificity protein phosphatase 15 (DUSP15)

Uniprot Id

Q9H1R2

Target Species

Human

Target Name

DUSP15

Target Full Name

Dual specificity protein phosphatase 15

Target Function

May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6.; May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation. Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination.

Target Subcellular Location

Cytoplasm.; [Isoform 3]: Cell membrane; Lipid-anchor; Cytoplasmic side.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily

Target Tissue Specificity

Highly expressed in testis. Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions.

Target Synonyms

bA243J16.5; Chromosome 20 open reading frame 57; Dual specificity phosphatase 15; Dual specificity phosphatase like 15; Dual specificity protein phosphatase 15; DUS15_HUMAN; DUSP15; EC 3.1.3.16; EC 3.1.3.48; FLJ20645; Vaccinia virus VH1 related dual specific protein phosphatase Y; Vaccinia virus VH1-related dual-specific protein phosphatase Y; VH1 related member Y; VH1-related member Y; VHY

Target Background

The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants.