Home Products Recombinant Human N-lysine methyltransferase SETD6 (SETD6)

Recombinant Human N-lysine methyltransferase SETD6 (SETD6)

ACP12746

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Specifications

Cat.No	ACP12746	Target Name	SETD6
Target Synonyms	SETD6; N-lysine methyltransferase SETD6; EC 2.1.1.-; SET domain-containing protein 6	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-473
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8TBK2

Background Information

Uniprot Id

Q8TBK2
Target Species

Human
Target Name

SETD6
Target Full Name

N-lysine methyltransferase SETD6
Target Function

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4.
Target Subcellular Location

Nucleus.
Target Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SETD6 subfamily
Target Synonyms

SETD6; N-lysine methyltransferase SETD6; EC 2.1.1.-; SET domain-containing protein 6
Target Background

This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants.

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Recombinant Human N-lysine methyltransferase SETD6 (SETD6)

Specifications

Immunogen Information

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