Recombinant Human Armadillo repeat-containing protein 10 (ARMC10), Truncated

Uniprot Id

Q8N2F6

Target Species

Human

Target Name

ARMC10

Target Full Name

Armadillo repeat-containing protein 10

Target Function

May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.

Target Tissue Specificity

Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.

Target Synonyms

ARM10_HUMAN; Armadillo repeat containing 10; Armadillo repeat containing protein 10; Armadillo repeat-containing protein 10; ARMC 10; ARMC10; FLJ37850; MGC3195; PNAS112; Specific splicing variant involved in hepatocarcinogenesis; Splicing variant involved in hepatocarcinogenesis protein; SVH

Target Background

This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.