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| Cat.No | ACP13400 | Target Name | ESX1 |
|---|---|---|---|
| Target Synonyms | ESX1; ESX1L; ESX1R; Homeobox protein ESX1; Extraembryonic; spermatogenesis; homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C] | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-406 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N693 |
|---|
Uniprot Id
Q8N693
Target Species
Human
Target Name
ESX1
Target Full Name
Homeobox protein ESX1
Target Function
May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
Target Subcellular Location
Cytoplasm. Nucleus. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Target Tissue Specificity
Expressed in placenta and testis. Expressed in testicular germ cell tumors.
Target Synonyms
ESX1; ESX1L; ESX1R; Homeobox protein ESX1; Extraembryonic; spermatogenesis; homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C]
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