Home Products Recombinant Human Patatin-like phospholipase domain-containing protein 1 (PNPLA1)

Recombinant Human Patatin-like phospholipase domain-containing protein 1 (PNPLA1)

ACP13684

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Specifications

Cat.No	ACP13684	Target Name	PNPLA1
Target Synonyms	PNPLA1; Patatin-like phospholipase domain-containing protein 1; EC 3.1.1.-	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-532
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8N8W4

Background Information

Uniprot Id

Q8N8W4
Target Species

Human
Target Name

PNPLA1
Target Full Name

Omega-hydroxyceramide transacylase
Target Function

Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation. Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide. Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function. These lipids also play a role in keratinocyte differentiation. May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS).
Target Involvement

Ichthyosis, congenital, autosomal recessive 10 (ARCI10)
Target Subcellular Location

Cytoplasm.
Target Tissue Specificity

Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in the region of keratin filament bundles, which is
Target Synonyms

PNPLA1; Patatin-like phospholipase domain-containing protein 1; EC 3.1.1.-

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Recombinant Human Patatin-like phospholipase domain-containing protein 1 (PNPLA1)

Specifications

Immunogen Information

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