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| Cat.No | ACP13710 | Target Name | LARGE2 |
|---|---|---|---|
| Target Synonyms | 3-glucuronyltransferase LARGE2; EC 2.4.1.-)], LARGE2; GYLTL1B; PP5656LARGE xylosyl- and glucuronyltransferase 2; EC 2.4.-.-; Glycosyltransferase-like 1B) [Includes: Xylosyltransferase LARGE2; EC 2.4.2.-); Beta-1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N3Y3 |
|---|
Uniprot Id
Q8N3Y3
Target Species
Human
Target Name
LARGE2
Target Full Name
Xylosyl- and glucuronyltransferase LARGE2
Target Function
Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Has a higher activity toward alpha-dystroglycan than LARGE
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 49 family; Glycosyltransferase 8 family
Target Tissue Specificity
Widely expressed. Expressed at high level in placenta, pancreas and kidney compared to LARGE. Not expressed in brain.
Target Synonyms
LARGE2; GYLTL1B; PP5656LARGE xylosyl- and glucuronyltransferase 2; EC 2.4.-.-; Glycosyltransferase-like 1B) [Includes: Xylosyltransferase LARGE2; EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE2; EC 2.4.1.-)]
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