Recombinant Human Selenoprotein M (SELENOM)

Uniprot Id

Q8WWX9

Target Species

Human

Target Name

SELENOM

Target Full Name

Selenoprotein M

Target Function

May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Target Subcellular Location

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.

Target Protein Families

Selenoprotein M/F family

Target Tissue Specificity

Widely expressed.

Target Research Area

Others

Target Synonyms

SELENOM; SELM; Selenoprotein M; SelM

Target Background

The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.