Recombinant Human V-type proton ATPase subunit G 3 (ATP6V1G3)

Uniprot Id

Q96LB4

Target Species

Human

Target Name

ATP6V1G3

Target Full Name

V-type proton ATPase subunit G 3

Target Function

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Target Protein Families

V-ATPase G subunit family

Target Tissue Specificity

Kidney.

Target Synonyms

ATP6G3; atp6v1g3; ATPase, H+ transporting, lysosomal (vacuolar proton pump) subunit G3; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3; MGC119810; MGC119813; MGC130213; MGC130214; V ATPase 13 kDa subunit 3; V ATPase G subunit 3; V ATPase G3 subunit; V ATPase subunit G 3; V-ATPase 13 kDa subunit 3; V-ATPase subunit G 3; V-type proton ATPase subunit G 3; Vacuolar ATP synthase subunit G 3; Vacuolar proton pump G subunit 3; Vacuolar proton pump subunit G 3; Vacuolar proton pump, subunit G3; VATG3_HUMAN; Vma10

Target Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.