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| Cat.No | ACP14419 | Target Name | RPUSD4 |
|---|---|---|---|
| Target Synonyms | RNA pseudouridylate synthase domain-containing protein 4; rpusd4; RUSD4_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-377 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96CM3 |
|---|
Uniprot Id
Q96CM3
Target Species
Human
Target Name
RPUSD4
Target Full Name
Pseudouridylate synthase RPUSD4, mitochondrial
Target Function
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation.
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Pseudouridine synthase RluA family
Target Synonyms
RNA pseudouridylate synthase domain-containing protein 4; rpusd4; RUSD4_HUMAN
Target Background
Enables mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Involved in mitochondrial tRNA pseudouridine synthesis and positive regulation of mitochondrial translation. Located in mitochondrion; nucleoplasm; and ribonucleoprotein granule.
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