Recombinant Human Inactive heparanase-2 (HPSE2)

Uniprot Id

Q8WWQ2

Target Species

Human

Target Name

HPSE2

Target Full Name

Inactive heparanase-2

Target Function

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).

Target Involvement

Urofacial syndrome 1 (UFS1)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Glycosyl hydrolase 79 family

Target Tissue Specificity

Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and

Target Synonyms

HPSE2; HPA2; Inactive heparanase-2; Hpa2

Target Background

This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.