Recombinant Human CUGBP Elav-like family member 6 (CELF6)

Uniprot Id

Q96J87

Target Species

Human

Target Name

CELF6

Target Full Name

CUGBP Elav-like family member 6

Target Function

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

CELF/BRUNOL family

Target Tissue Specificity

Expressed mainly in kidney, brain and testis and present in other tissues albeit at lower levels. Also expressed in fetal kidney.

Target Synonyms

6330569O16Rik; Bruno like 6; RNA binding protein (Drosophila); bruno like 6; RNA binding protein; Bruno like protein 6; Bruno-like protein 6; BRUNOL6; CELF-6; Celf6; CELF6_HUMAN; CUG-BP- and ETR-3-like factor 6; CUGBP and ETR3 like factor 6; CUGBP Elav-like family member 6; RNA binding protein BRUNOL 6; RNA-binding protein BRUNOL-6

Target Background

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.