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| Cat.No | ACP14991 | Target Name | MISP |
|---|---|---|---|
| Target Synonyms | chromosome 19 open reading frame 21; hypothetical protein LOC126353; Misp; MISP_HUMAN; Mitotic interactor and substrate of PLK1; Mitotic spindle positioning protein; Uncharacterized protein C19orf21 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-679 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IVT2 |
|---|
Uniprot Id
Q8IVT2
Target Species
Human
Target Name
MISP
Target Full Name
Mitotic interactor and substrate of PLK1
Target Function
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.
Target Subcellular Location
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.
Target Protein Families
MISP family
Target Synonyms
chromosome 19 open reading frame 21; hypothetical protein LOC126353; Misp; MISP_HUMAN; Mitotic interactor and substrate of PLK1; Mitotic spindle positioning protein; Uncharacterized protein C19orf21
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