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| Cat.No | ACP15224 | Target Name | PNPLA6 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IY17 |
|---|
Uniprot Id
Q8IY17
Target Species
Human
Target Name
PNPLA6
Target Full Name
Patatin-like phospholipase domain-containing protein 6
Target Function
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids. Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides.
Target Involvement
Spastic paraplegia 39, autosomal recessive (SPG39); Boucher-Neuhauser syndrome (BNHS); Laurence-Moon syndrome (LNMS); Oliver-McFarlane syndrome (OMCS)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Target Protein Families
NTE family
Target Tissue Specificity
Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain.
Target Synonyms
EC 3.1.1.5; Neuropathy target esterase; NTEMND; Patatin like phospholipase domain containing 6; Patatin like phospholipase domain containing protein 6; Patatin-like phospholipase domain-containing protein 6; PLPL6_HUMAN; Pnpla6; SPG39; sws
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