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Recombinant Human Centriolin (CNTRL), Truncated

ACP15431

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Specifications

Cat.No	ACP15431	Target Name	CNTRL
Target Synonyms	CNTRL; CEP1; CEP110Centriolin; Centrosomal protein 1; Centrosomal protein of 110 kDa; Cep110	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q7Z7A1

Background Information

Uniprot Id

Q7Z7A1
Target Species

Human
Target Name

CNTRL
Target Full Name

Centriolin
Target Function

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.
Target Involvement

A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
Target Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring.
Target Tissue Specificity

Widely expressed with highest levels in testis and trachea.
Target Synonyms

CNTRL; CEP1; CEP110Centriolin; Centrosomal protein 1; Centrosomal protein of 110 kDa; Cep110

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Recombinant Human Centriolin (CNTRL), Truncated

Specifications

Immunogen Information

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