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| Cat.No | ACP15569 | Target Name | CCDC84 |
|---|---|---|---|
| Target Synonyms | CCD84_HUMAN; Ccdc84; Coiled-coil domain-containing protein 84; DLNB14 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-332 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86UT8 |
|---|
Uniprot Id
Q86UT8
Target Species
Human
Target Name
CENATAC
Target Full Name
Centrosomal AT-AC splicing factor
Target Function
Negative regulator of centrosome duplication. Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1.
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Synonyms
CCD84_HUMAN; Ccdc84; Coiled-coil domain-containing protein 84; DLNB14
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