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| Cat.No | ACP15683 | Target Name | CCDC25 |
|---|---|---|---|
| Target Synonyms | CCDC25Coiled-coil domain-containing protein 25 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-208 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86WR0 |
|---|
Uniprot Id
Q86WR0
Target Species
Human
Target Name
CCDC25
Target Full Name
Coiled-coil domain-containing protein 25
Target Function
Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells. Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells. In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells.
Target Subcellular Location
Cell membrane; Single-pass membrane protein. Endomembrane system.
Target Protein Families
CCDC25 family
Target Synonyms
CCDC25Coiled-coil domain-containing protein 25
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