Recombinant Human NACHT, LRR and PYD domains-containing protein 9 (NLRP9), Truncated

Uniprot Id

Q7RTR0

Target Species

Human

Target Name

NLRP9

Target Full Name

NACHT, LRR and PYD domains-containing protein 9

Target Function

As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.

Target Subcellular Location

Cytoplasm. Inflammasome.

Target Protein Families

NLRP family

Target Tissue Specificity

Expressed in ileum intestinal epithelial cells. Not detected in peripheral blood mononuclear cells. Expressed in cerebral endothelial cells and, at much lower levels, in brain pericytes.

Target Synonyms

NACHT, LRR and PYD domains-containing protein 9; NALP9_HUMAN; NLRP9; Nucleotide-binding oligomerization domain protein 6; PYRIN and NACHT-containing protein 12