Recombinant HumanIsoaspartyl peptidase/L-asparaginase (ASRGL1), Truncated

Uniprot Id

Q7L266

Target Species

Human

Target Name

ASRGL1

Target Full Name

Isoaspartyl peptidase/L-asparaginase

Target Function

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.

Target Subcellular Location

Cytoplasm. Note=Midpiece of sperm tail.

Target Protein Families

Ntn-hydrolase family

Target Tissue Specificity

Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma.

Target Synonyms

ASRGL1; ALP; CRASHIsoaspartyl peptidase/L-asparaginase; EC 3.4.19.5; EC 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]