Recombinant Human Iodotyrosine dehalogenase 1 (IYD), Truncated

Uniprot Id

Q6PHW0

Target Species

Human

Target Name

IYD

Target Full Name

Iodotyrosine deiodinase 1

Target Function

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.

Target Involvement

Thyroid dyshormonogenesis 4 (TDH4)

Target Subcellular Location

Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.

Target Protein Families

Nitroreductase family

Target Tissue Specificity

Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.

Target Synonyms

IYD; C6orf71; DEHAL1; Iodotyrosine deiodinase 1; IYD-1; EC 1.21.1.1; Iodotyrosine dehalogenase 1

Target Background

This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.