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| Cat.No | ACP16579 | Target Name | CYP4F22 |
|---|---|---|---|
| Target Synonyms | CYP4F22Cytochrome P450 4F22; EC 1.14.14.- | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-531 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6NT55 |
|---|
Uniprot Id
Q6NT55
Target Species
Human
Target Name
CYP4F22
Target Full Name
Ultra-long-chain fatty acid omega-hydroxylase
Target Function
A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis. Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Target Involvement
Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein.
Target Protein Families
Cytochrome P450 family
Target Synonyms
CYP4F22Cytochrome P450 4F22; EC 1.14.14.-
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