Recombinant Human 2,4-dienoyl-CoA reductase, mitochondrial (DECR1)

Uniprot Id

Q16698

Target Species

Human

Target Name

DECR1

Target Full Name

2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

Target Function

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

Target Involvement

2,4-dienoyl-CoA reductase deficiency (DECRD)

Target Subcellular Location

Mitochondrion.

Target Protein Families

Short-chain dehydrogenases/reductases (SDR) family, 2,4-dienoyl-CoA reductase subfamily

Target Tissue Specificity

Heart = liver = pancreas > kidney >> skeletal muscle = lung.

Target Synonyms

1200012F07Rik; 2; 2,4 dienoyl CoA reductase [NADPH]; 2,4 dienoyl CoA reductase 1; 2,4 dienoyl CoA reductase mitochondrial; 2,4-dienoyl-CoA reductase; mitochondrial; 4 enoyl CoA reductase; 4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH]; DECR 1; DECR; DECR_HUMAN; DECR1; Nadph; OTTMUSP00000004962; RP23-338J24.3; SDR18C1; Short chain dehydrogenase/reductase family 18C member 1

Target Background

Enables 2, 4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in fatty acid beta-oxidation. Located in cytosol; mitochondrion; and nucleoplasm. Part of catalytic complex.