Recombinant Human Alpha-globin transcription factor CP2 (TFCP2)

Uniprot Id

Q12800

Target Species

Human

Target Name

TFCP2

Target Full Name

Alpha-globin transcription factor CP2

Target Function

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1. Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.

Target Subcellular Location

Nucleus.

Target Protein Families

Grh/CP2 family, CP2 subfamily

Target Tissue Specificity

Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).

Target Synonyms

Alpha globin transcription factor CP2; Alpha-globin transcription factor CP2; CP2; Late SV40 factor; LBP 1C; LBP1C; LSF; LSF1D; SAA3 enhancer factor; SEF; TFCP2; TFCP2_HUMAN; TFCP2C; Transcription factor CP2; Transcription factor LSF

Target Background

This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease.