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Recombinant Human Dedicator of cytokinesis protein 1 (DOCK1), Truncated

ACP18053

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP18053 Target NameDOCK1
Target Synonyms180 kDa protein downstream of CRK; Ced5; Dedicator of Cytokinesis 1; Dedicator of cytokinesis protein 1; DOCK 1; DOCK 180; DOCK1; DOCK1_HUMAN; DOCK180FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Protein LengthPartial
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ14185
Background Information
  • Uniprot Id

    Q14185

  • Target Species

    Human

  • Target Name

    DOCK1

  • Target Full Name

    Dedicator of cytokinesis protein 1

  • Target Function

    Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.

  • Target Subcellular Location

    Cytoplasm. Membrane.

  • Target Protein Families

    DOCK family

  • Target Tissue Specificity

    Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.

  • Target Synonyms

    180 kDa protein downstream of CRK; Ced5; Dedicator of Cytokinesis 1; Dedicator of cytokinesis protein 1; DOCK 1; DOCK 180; DOCK1; DOCK1_HUMAN; DOCK180

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