Recombinant Human Transcription initiation factor TFIID subunit 13 (TAF13)

Uniprot Id

Q15543

Target Species

Human

Target Name

TAF13

Target Full Name

Transcription initiation factor TFIID subunit 13

Target Function

Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells.

Target Involvement

Mental retardation, autosomal recessive 60 (MRT60)

Target Subcellular Location

Nucleus.

Target Protein Families

TAF13 family

Target Synonyms

MGC22425 ; TAF(II)18; taf13; TAF13 RNA polymerase II; TATA box binding protein (TBP) associated factor; 18kDa; TAF13_HUMAN; TAF2K; TAFII 18; TAFII-18; TAFII18; Transcription initiation factor TFIID 18 kDa subunit; Transcription initiation factor TFIID subunit 13

Target Background

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6.