Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP19144 | Target Name | ASCC2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-757 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H1I8 |
|---|
Uniprot Id
Q9H1I8
Target Species
Human
Target Name
ASCC2
Target Full Name
Activating signal cointegrator 1 complex subunit 2
Target Function
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes.
Target Subcellular Location
Nucleus. Nucleus speckle.
Target Protein Families
ASCC2 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
1700011I11Rik; 2610034L15Rik; Activating signal cointegrator 1 complex subunit 2; AI482016; ASC 1 complex subunit p100; ASC-1 complex subunit p100; ASC1P100; ASCC 2; Ascc2; ASCC2_HUMAN; AW046480; FLJ21588; OTTMUSP00000005258; p100; RGD1561422; RP23-280J3.3; Trip4 complex subunit p100
Target Background
Predicted to enable ubiquitin binding activity. Involved in regulation of transcription, DNA-templated; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of activating signal cointegrator 1 complex.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
