Recombinant Human E3 ubiquitin-protein ligase HERC2 (HERC2), Truncated

Uniprot Id

O95714

Target Species

Human

Target Name

HERC2

Target Full Name

E3 ubiquitin-protein ligase HERC2

Target Function

E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway

Target Involvement

Mental retardation, autosomal recessive 38 (MRT38)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.

Target Synonyms

D15F37S1; E3 ubiquitin-protein ligase HERC2; HECT and RLD domain containing E3 ubiquitin protein ligase 2; HECT domain and RCC1 like domain containing protein 2; HECT domain and RCC1-like domain-containing protein 2; Hect domain and RLD 2; HERC2; HERC2_HUMAN; jdf2 ; MRT38; p528 ; Probable E3 ubiquitin-protein ligase HERC2; SHEP1