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| Cat.No | ACP20574 | Target Name | ATP6V1G1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-118 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75348 |
|---|
Uniprot Id
O75348
Target Species
Human
Target Name
ATP6V1G1
Target Full Name
V-type proton ATPase subunit G 1
Target Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.
Target Subcellular Location
Apical cell membrane.
Target Protein Families
V-ATPase G subunit family
Target Tissue Specificity
Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level). Ubiquitous.
Target Research Area
Transport
Target Synonyms
ATP 6G; ATP 6J; ATP6G; ATP6G1; ATP6GL; Atp6v1g1; ATPase H+ transporting lysosomal (vacuolar proton pump) member J; ATPase H+ transporting lysosomal 13kD V1 subunit G isoform 1; ATPase H+ transporting lysosomal 13kDa V1 subunit G1; ATPase H+ transporting lysosomal member J; ATPase H+ transporting lysosomal subunit G isoform 1; DKFZp547P234; V ATPase 13 kDa subunit 1; V ATPase G subunit 1; V-ATPase 13 kDa subunit 1; V-ATPase subunit G 1; V-type proton ATPase subunit G 1; Vacuolar ATP synthase subunit G 1; Vacuolar ATP synthase subunit G1; Vacuolar ATP synthase subunit M16; Vacuolar H+ ATPase G1; Vacuolar H+ ATPase subunit G 1; Vacuolar proton pump G subunit 1; Vacuolar proton pump subunit G 1; Vacuolar proton pump subunit M16; VATG1_HUMAN; Vma 10; Vma10
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