Recombinant Human Synaptojanin-1 (SYNJ1), Truncated

Cat.No	ACP20957	Target Name	SYNJ1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP20957

Target Name

SYNJ1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O43426

Background Information

Uniprot Id

O43426
Target Species

Human
Target Name

SYNJ1
Target Full Name

Synaptojanin-1
Target Function

Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2.
Target Involvement

Parkinson disease 20, early-onset (PARK20); Epileptic encephalopathy, early infantile, 53 (EIEE53)
Target Subcellular Location

Cytoplasm, perinuclear region.
Target Protein Families

Synaptojanin family; Inositol 1,4,5-trisphosphate 5-phosphatase family
Target Tissue Specificity

Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals.
Target Synonyms

4; 5-trisphosphate 5-phosphatase 1; Inositol 5' phosphatase (synaptojanin 1); Inositol 5' phosphatase; INPP 5G; INPP5G; KIAA0910; PARK20; Polyphosphoinositide phosphatase; Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 1; Synaptic inositol 145 trisphosphate 5 phosphatase 1; Synaptic inositol-1; Synaptojanin 1; Synaptojanin 1 polyphosphoinositide phosphatase; Synaptojanin-1; Synaptojanin1; Synj 1; Synj1; SYNJ1_HUMAN
Target Background

This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4, 5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Synaptojanin-1 (SYNJ1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Synaptojanin-1 (SYNJ1), Truncated Now

Related Products