Recombinant Human Orexin (HCRT), Truncated

Uniprot Id

O43612

Target Species

Human

Target Name

HCRT

Target Full Name

Hypocretin neuropeptide precursor

Target Function

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

Target Involvement

Narcolepsy 1 (NRCLP1)

Target Subcellular Location

Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse.

Target Protein Families

Orexin family

Target Tissue Specificity

Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Target Synonyms

Hcrt; Hcrt1; Hcrt2; Hypocretin; Hypocretin neuropeptide precursor; Hypocretin-1; Hypocretin-2; OREX_HUMAN; Orexin; Orexin precursor; Orexin-B; OX; PPOX

Target Background

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.