Recombinant Human Homeobox protein Hox-B5 (HOXB5)

Uniprot Id

P09067

Target Species

Human

Target Name

HOXB5

Target Full Name

Homeobox protein Hox-B5

Target Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Target Subcellular Location

Nucleus.

Target Protein Families

Antp homeobox family

Target Tissue Specificity

Spinal cord.

Target Synonyms

HGNC:5116; HHO.C10; Homeo box 2A; Homeo box B5; Homeobox 2A; Homeobox B5; Homeobox protein HHO.C10; Homeobox protein Hox B5; Homeobox protein Hox-2A; Homeobox protein Hox-B5; Homeobox protein HoxB5; Homeobox protein Hu-1; Homeobox2A; HomeoboxB5; HOX 2; Hox 2.1; HOX 2A; HOX B5; HOX2; Hox2.1; Hox2.1, mouse, homolog of; HOX2A; HOXB 5; Hoxb5; HU 1; HU1; HXB5_HUMAN

Target Background

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.