Recombinant Human Heme oxygenase 1 (HMOX1)

Uniprot Id

P09601

Target Species

Human

Target Name

HMOX1

Target Full Name

Heme oxygenase 1

Target Function

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

Target Involvement

Heme oxygenase 1 deficiency (HMOX1D)

Target Subcellular Location

Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Heme oxygenase family

Target Tissue Specificity

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).

Target Research Area

Cardiovascular

Target Synonyms

32 kD; bK286B10; D8Wsu38e; heat shock protein 32 kD; heat shock protein 32kD; Heat shock protein; Heme oxygenase (decycling) 1; Heme oxygenase 1; Hemox; HMOX 1; Hmox; Hmox1; HMOX1_HUMAN; HO 1; HO; HO-1; HO1 ; Hsp32

Target Background

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.