Recombinant Human Histamine N-methyltransferase (HNMT)

Uniprot Id

P50135

Target Species

Human

Target Name

HNMT

Target Full Name

Histamine N-methyltransferase

Target Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.

Target Involvement

Mental retardation, autosomal recessive 51 (MRT51)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, HNMT family

Target Synonyms

EC 2.1.1.8; Histamine N methyltransferase; Histamine N-methyltransferase; HMT; HNMT; HNMT S1; HNMT S2; HNMT_HUMAN

Target Background

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.