Recombinant Human GMP synthase [glutamine-hydrolyzing] (GMPS)

Uniprot Id

P49915

Target Species

Human

Target Name

GMPS

Target Full Name

GMP synthase [glutamine-hydrolyzing]

Target Function

Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

Target Involvement

A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.

Target Subcellular Location

Cytoplasm.

Target Synonyms

GATD7; Glutamine amidotransferase; GMP synthase [glutamine hydrolyzing]; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Gmps; GUAA_HUMAN; Guanine monophosphate synthase; Guanine monphosphate synthetase; Guanosine 5' monophosphate synthase; MLL/GMPS fusion protein; Testicular tissue protein Li 82

Target Background

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.