Recombinant Human Electron transfer flavoprotein subunit beta (ETFB)

Uniprot Id

P38117

Target Species

Human

Target Name

ETFB

Target Full Name

Electron transfer flavoprotein subunit beta

Target Function

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.

Target Involvement

Glutaric aciduria 2B (GA2B)

Target Subcellular Location

Mitochondrion matrix.

Target Protein Families

ETF beta-subunit/FixA family

Target Tissue Specificity

Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.

Target Synonyms

Beta ETF; Beta-ETF; Electron transfer flavoprotein beta polypeptide ; Electron transfer flavoprotein beta subunit ; Electron transfer flavoprotein subunit beta; Electron transferring flavoprotein beta polypeptide ; etfB; ETFB_HUMAN; FP585; MADD

Target Background

This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene.