Recombinant Human Cytochrome P450 4B1 (CYP4B1)

Uniprot Id

P13584

Target Species

Human

Target Name

CYP4B1

Target Full Name

Cytochrome P450 4B1

Target Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Target Protein Families

Cytochrome P450 family

Target Tissue Specificity

Detected in the liver and lung (at protein level).

Target Synonyms

CP4B1_HUMAN; CYP4B1; CYPIVB1; Cytochrome P450 4B1; Cytochrome P450 family 4 subfamily B polypeptide 1; Cytochrome P450 subfamily IVB polypeptide 1; Cytochrome P450-HP; Microsomal monooxygenase; P450HP

Target Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene.