Rabbit anti-Human AMH Polyclonal Antibody

Uniprot Id

P03971

Target Species

Human

Target Name

AMH

Target Full Name

Muellerian-inhibiting factor

Target Function

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

Target Involvement

Persistent Muellerian duct syndrome 1 (PMDS1)

Target Subcellular Location

Secreted.

Target Protein Families

TGF-beta family

Target Synonyms

MIF; MIS; AMH

Target Background

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.