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The antibody against HBZ was raised in rabbit using the Recombinant Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) HBZ protein (1-209aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
The antibody against HBZ was raised in rabbit using the Recombinant Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) HBZ protein (1-209aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
$299.00
Western Blot | Positive WB detected in: recombinant protein | All lanes: HBZ Antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 47 kDa | Observed band size: 47 kDa
| Cat.No | ADC-55315A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HBZ |
| Target Synonyms | HTLV-1 basic zipper factor (HBZ) HBZ | Form | Liquid |
| Species Reactivity | Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Affinity-chromatography purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) HBZ protein (1-209aa) | Target Species | Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P0C745 |
Uniprot Id
P0C745
Target Species
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)
Target Name
HBZ
Target Function
Enhances viral infectivity and persistence, and facilitates proliferation of HTLV-1-infected lymphocytes. Mechanistically, inhibits Tax-mediated viral replication and NF-kappa-B activation. Plays a role in allowing infected T-cells to escape the cytotoxic T-lymphocyte response by maintaining low levels of viral protein production. Inhibits also host EP300 histone acetyltransferase (HAT) activity, reducing levels of acetylated histone H3 at 'Lys-18' (H3K18ac) in infected cells. Contributes to the accumulation of chromosomal abnormalities by inhibiting double-stranded DNA breaks (DSB) repair through the NHEJ pathway. Participates in the modulation of host immune response at multiple levels contributing to abnormal interferon signaling and viral pathogenesis.
Target Subcellular Location
Host nucleus.
Target Protein Families
HTLV-1 HBZ protein family
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