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The antibody against SOCS4 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 340-440 of human SOCS4 (NP_543143.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SOCS4 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 340-440 of human SOCS4 (NP_543143.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using SOCS4 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
| Cat.No | ADA-00037A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SOCS4 |
| Target Synonyms | SOCS7; SOCS4 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, NIH/3T3, K-562 | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 340-440 of human SOCS4 (NP_543143.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | SKVRVLRIDAPEQQC | Uniprot ID | Q8WXH5 |
Uniprot Id
Q8WXH5
Target Species
Human
Target Name
SOCS4
Target Full Name
Suppressor of cytokine signaling 4
Target Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
Target Synonyms
CIS4; Cish4; Cytokine inducible SH2 protein 4; DKFZp686J1568; HSPC060; SH2 domain containing SOCS box protein; SOCS-4; SOCS-7; SOCS4; SOCS4_HUMAN; SOCS6; SOCS7; SSI4; STAI4; STAT induced STAT inhibitor 4; STAT4; STATI4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 7
Target Background
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
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