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The antibody against ZIC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ZIC3 (NP_003404.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZIC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ZIC3 (NP_003404.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00984A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZIC3 |
| Target Synonyms | HTX; HTX1; ZNF203; VACTERLX; ZIC3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, MCF7, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ZIC3 (NP_003404.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O60481 | Immunogen Sequence |
Uniprot Id
O60481
Target Species
Human
Target Name
ZIC3
Target Full Name
Zinc finger protein ZIC 3
Target Function
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Target Involvement
Heterotaxy, visceral, 1, X-linked (HTX1); VACTERL association X-linked with or without hydrocephalus (VACTERLX); Congenital heart defects, multiple types, 1, X-linked (CHTD1)
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
GLI C2H2-type zinc-finger protein family
Target Synonyms
Heterotaxy 1; HTX; HTX1; VACTERLX; ZIC 3; Zic family member 3 (odd paired Drosophila homolog heterotaxy 1); Zic family member 3; Zic3; ZIC3_HUMAN; Zinc finger protein 203; Zinc finger protein of the cerebellum 3; Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3); Zinc finger protein ZIC 3; ZNF203
Target Background
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
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