Rabbit anti-Human ARPC3 Polyclonal Antibody

The antibody against ARPC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human ARPC3 (NP_001265485.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-01955A

Number

Cat.No	ADA-01955A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ARPC3
Target Synonyms	ARC21; p21-Arc; ARPC3	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse lung, Mouse spleen, Rat ovary, SH-SY5Y, SKOV3, U-251MG	Application	ELISA, WB, IF/ICC

Cat.No

ADA-01955A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ARPC3

Target Synonyms

ARC21; p21-Arc; ARPC3

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse lung, Mouse spleen, Rat ovary, SH-SY5Y, SKOV3, U-251MG

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human ARPC3 (NP_001265485.1).	Target Species	Human
Immunogen Sequence	MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ	Uniprot ID	O15145

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human ARPC3 (NP_001265485.1).

Target Species

Human

Immunogen Sequence

MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ

Uniprot ID

O15145

Background Information

Uniprot Id

O15145
Target Species

Human
Target Name

ARPC3
Target Full Name

Actin-related protein 2/3 complex subunit 3
Target Function

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Target Protein Families

ARPC3 family
Target Research Area

Signal Transduction
Target Synonyms

ARPC3; ARC21Actin-related protein 2/3 complex subunit 3; Arp2/3 complex 21 kDa subunit; p21-ARC
Target Background

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene.

Rabbit anti-Human ARPC3 Polyclonal Antibody

Specifications

Immunogen Information

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