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The antibody against OSTM1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 32-284 of human OSTM1 (NP_054747.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against OSTM1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 32-284 of human OSTM1 (NP_054747.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02019A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OSTM1 |
| Target Synonyms | GL; GIPN; OPTB5; HSPC019; OSTM1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, 293T, A-549, B cells, Mouse brain, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 32-284 of human OSTM1 (NP_054747.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q86WC4 | Immunogen Sequence |
Uniprot Id
Q86WC4
Target Species
Human
Target Name
OSTM1
Target Full Name
Osteopetrosis-associated transmembrane protein 1
Target Function
Required for osteoclast and melanocyte maturation and function.
Target Involvement
Osteopetrosis, autosomal recessive 5 (OPTB5)
Target Subcellular Location
Lysosome membrane; Single-pass type I membrane protein. Note=Requires CLCN7 to travel to lysosomes.
Target Protein Families
OSTM1 family
Target Synonyms
Chloride channel 7 beta subunit; GAIP-interacting protein N terminus; GIPN; GL; Grey lethal osteopetrosis; HSPC019; OPTB5; Osteopetrosis-associated transmembrane protein 1; Ostm1; OSTM1_HUMAN; OTTHUMP00000016938; OTTHUMP00000196342
Target Background
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.
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