Rabbit anti-Human APOBEC3F Polyclonal Antibody

Uniprot Id

Q8IUX4

Target Species

Human

Target Name

APOBEC3F

Target Full Name

DNA dC->dU-editing enzyme APOBEC-3F

Target Function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Target Subcellular Location

Cytoplasm. Cytoplasm, P-body.

Target Protein Families

Cytidine and deoxycytidylate deaminase family

Target Tissue Specificity

Widely expressed. Highly expressed in ovary.

Target Synonyms

A3F; ABC3F_HUMAN; APOBEC3F; Apolipoprotein B mRNA editing enzyme; catalytic polypeptide like 3F; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F; ARP8; DNA dC->dU-editing enzyme APOBEC-3F; Induced upon T cell activation; KA6

Target Background

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.