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The antibody against LAX1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against LAX1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02250A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LAX1 |
| Target Synonyms | LAX; LAX1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8IWV1 | Immunogen Sequence |
Uniprot Id
Q8IWV1
Target Species
Human
Target Name
LAX1
Target Full Name
Lymphocyte transmembrane adapter 1
Target Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
Target Subcellular Location
Cell membrane; Single-pass type III membrane protein.
Target Tissue Specificity
Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.
Target Synonyms
LAX1; LAX; Lymphocyte transmembrane adapter 1; Linker for activation of X cells; Membrane-associated adapter protein LAX
Target Background
Enables SH2 domain binding activity and protein kinase binding activity. Involved in several processes, including B cell activation; negative regulation of MAP kinase activity; and negative regulation of T cell activation. Located in Golgi apparatus; cytosol; and plasma membrane. Is integral component of membrane.
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