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The antibody against THAP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human THAP1 (NP_060575.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against THAP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human THAP1 (NP_060575.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02489A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | THAP1 |
| Target Synonyms | DYT6; THAP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse liver, Mouse thymus, Rat liver | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human THAP1 (NP_060575.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NVV9 | Immunogen Sequence |
Uniprot Id
Q9NVV9
Target Species
Human
Target Name
THAP1
Target Full Name
THAP domain-containing protein 1
Target Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Target Involvement
Dystonia 6, torsion (DYT6)
Target Subcellular Location
Nucleus, nucleoplasm. Nucleus, PML body.
Target Protein Families
THAP1 family
Target Tissue Specificity
Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.
Target Synonyms
4833431A01Rik; DYT6; FLJ10477; MGC33014; Nuclear proapoptotic factor; THAP 1; THAP domain containing 1; THAP domain containing apoptosis associated protein 1; THAP domain containing protein 1; THAP domain protein 1; THAP domain-containing protein 1; Thap1; THAP1_HUMAN
Target Background
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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