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The antibody against MOGS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human MOGS (NP_006293.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MOGS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human MOGS (NP_006293.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03208A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MOGS |
| Target Synonyms | DER7; GCS1; CDG2B; CWH41; MOGS | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BxPC-3, LO2, Mouse brain, Mouse liver, Mouse pancreas, Mouse testis, OVCAR-3, Rat liver, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human MOGS (NP_006293.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13724 | Immunogen Sequence |
Uniprot Id
Q13724
Target Species
Human
Target Name
MOGS
Target Full Name
Mannosyl-oligosaccharide glucosidase
Target Function
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.
Target Involvement
Type IIb congenital disorder of glycosylation (CDGIIb)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyl hydrolase 63 family
Target Synonyms
EC 3.2.1.106; glucosidase I; Mannosyl oligosaccharide glucosidase; Mannosyl-oligosaccharide glucosidase; Mogs; MOGS_HUMAN; Processing A glucosidase I; Processing A-glucosidase I
Target Background
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1, 2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene.
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